|
Field Name |
Explanation |
|
Gene |
Region of the genome in which the mutation occurs. Protein affected by the mutation. |
|
Wild Type AA |
The "wild-type" amino acid normally found at a given position. Amino acid abbreviations are here. |
|
AA Position |
The position of the mutation expressed as number of amino acids from the start of the protein. |
|
Mutant AA |
The identity of the amino acid resulting from the mutation. Amino acid abbreviations are here. |
|
Wild Type Codon |
The "wild-type" codon normally found at this position. |
|
Mutant Codon |
The codon(s) resulting from the mutation. |
|
DrugClass |
The category of drug whose efficacy is affected by the mutation. |
|
Compound |
The name of the drug or compound. An index of compound names is here. |
|
Drug Names |
Other names used for the same compound; e.g, compound DMP-266 is also known as efavirenz and Sustiva. |
|
In Vitro |
Resistance effects have been observed in cloned virus or cell culture studies. |
|
In Vivo |
Resistance or cross-resistance effects have been observed in patients. |
|
Select or Cross-Resist |
How mutations were identified. Selected refers to mutations identified from patients on a specific drug therapy, or from in vitro passage of virus in increasing concentrations of a compound to select for resistance-conferring mutations. Cross-R means that virus with a mutation has decreased susceptibility to a compound that did not select for that mutation. |
|
Comment |
Comments, usually about synergistic effects of other mutations. |
|
Cite |
Reference citation of the form Williams97. |
|
Authors |
All authors of papers associated with this record. |
|
Title |
Article title. |
|
Journal |
Journal name, often abbreviated in the Medline style. |
|
Volume |
Journal volume. |
|
Page |
Page numbers of references. |
|
Year |
Four-digit year of publication of reference, e.g. 1997. |
|
Medline |
The Medline unique identifier number. Displayed as an active link to Medline, like this, 98241751. |